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KMID : 0811720130170040267
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Korean Journal of Physiology & Pharmacology
2013 Volume.17 No. 4 p.267 ~ p.274
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Curcumin Attenuates Radiation-Induced Inflammation and Fibrosis in Rat Lungs
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Cho Yu-Ji
Yi Chin-Ok
Jeon Byeong-Tak
Jeong Yi-Yeong
Kang Gi-Mun
Lee Jung-Eun
Roh Gu-Seob
Lee Jong-Deog
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Abstract
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A beneficial radioprotective agent has been used to treat the radiation-induced lung injury. This study was performed to investigate whether curcumin, which is known to have anti-inflammatory and antioxidant properties, could ameliorate radiation-induced pulmonary inflammation and fibrosis in irradiated lungs. Rats were given daily doses of intragastric curcumin (200 mg/kg) prior to a single irradiation and for 8 weeks after radiation. Histopathologic findings demonstrated that macrophage accumulation, interstitial edema, alveolar septal thickness, perivascular fibrosis, and collapse in radiation-treated lungs were inhibited by curcumin administration. Radiation-induced transforming growth factor-?1 (TGF-?1), connective tissue growth factor (CTGF) expression, and collagen accumulation were also inhibited by curcumin. Moreover, western blot analysis revealed that curcumin lowered radiation-induced increases of tumor necrosis factor-? (TNF-?), TNF receptor 1 (TNFR1), and cyclooxygenase-2 (COX-2). Curcumin also inhibited the nuclear translocation of nuclear factor-?B (NF-?B) p65 in radiation-treated lungs. These results indicate that long-term curcumin administration may reduce lung inflammation and fibrosis caused by radiation treatment.
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KEYWORD
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Curcumin, Fibrosis, Inflammation, Lung, Radiation
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